Vertical bone defects are an indication for a regenerative procedure to restore all structural elements of the periodontium. The prerequisite for success is adequate preparation of the patient for the procedure and the selection of the optimal regeneration strategy. In the case of bone defects, which cannot be cleaned from the buccal side, it is advisable to dissect the gingival papillae. In the case presented here, the procedure was performed according to the concept of minimally invasive surgical technique (MIST). The root surfaces were cleaned using ultrasound and hand instruments and then biomodified with 24% EDTA and enamel matrix protein (Emdogain). The bone defect was filled with shavings of radiation-sterilised allogeneic bone, which was mixed with Emdogain. Due to the thin phenotype, an autogenous subepithelial connective tissue graft (SCTG) was sutured under the buccal flap. Horizontal suturing was used to close the wound. The sutures were removed after 14 days. The final photos show the clinical situation 6 months after surgery.